業績

論文一覧はこちらから

主要論文

  • Takano, T. et al. Chemico-genetic discovery of astrocytic control of inhibition in vivo. Nature 588, 296–302 (2020). [Pubmed]
  • Ito, Y., Nagamoto, S. & Takano, T. Synaptic proteomics decode novel molecular landscape in the brain. Front. Mol. Neurosci. 17, (2024). [Pubmed]
  • Takano, T. & Soderling, S. H. Tripartite synaptomics: Cell-surface proximity labeling in vivo. Neuroscience Research 173, 14–21 (2021).[Pubmed]
  • Takano, T. et al. Discovery of long-range inhibitory signaling to ensure single axon formation. Nat Commun 8, 33 (2017).[Pubmed]

2025年

  • Yamamoto M, Takano T. Astrocyte-Mediated Plasticity: Multi-Scale Mechanisms Linking Synaptic Dynamics to Learning and Memory. Cells. (24):1936. (2025). [DOI]
  • Shiyi W, Ryan B, Gabrielle S, Dhanesh S. B, Kylie D, Kristina S, Leslie V, Jessica L. M, Christabel X. Tan, Tetsuya T, et al. PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation. eLife. 14:RP107556. (2025). [DOI]
  • Junpei M, Takano T. Proximity labeling uncovers the synaptic proteome under physiological and pathological conditions. Front. Cell. Neurosci. 19:1638627. (2025).[DOI]
  • Hosokawa T, Kubota Y, & Takano T. Spatio-temporal Molecular Mechanisms Regulating Synapse Function and Neural Circuit Dynamics, Front. Mol. Neurosci. 18, (2025). [DOI]

2024年

  • Ito, Y. & Takano, T. Recording calcium concentrations. Nat Chem Biol 20, 805–806 (2024).[Pubmed]
  • Ito, Y., Nagamoto, S. & Takano, T. Synaptic proteomics decode novel molecular landscape in the brain. Front. Mol. Neurosci. 17, (2024).[Pubmed]

~2023年

  • Takano, T. Comprehensive identification of molecules at synapses and non-synaptic cell-adhesion structure. impact 2023, 46–48 (2023).
  • Wu, M. et al. Rho–Rho-Kinase Regulates Ras-ERK Signaling Through SynGAP1 for Dendritic Spine Morphology. Neurochem Res 47, 2757–2772 (2022).[Pubmed]
  • Im, D. S. et al. Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibition. BMC Biol 20, 115 (2022).[Pubmed]
  • Takano, T. & Soderling, S. H. Tripartite synaptomics: Cell-surface proximity labeling in vivo. Neuroscience Research 173, 14–21 (2021).[Pubmed]
  • Komaki, K. et al. Lemur tail kinase 1 (LMTK1) regulates the endosomal localization of β-secretase BACE1. The Journal of Biochemistry 170, 729–738 (2021).[Pubmed]
  • Nagamoto, S. et al. Short term but highly efficient Cas9 expression mediated by excisional system using adenovirus vector and Cre. Sci. Reports 2021 111 11, 1–10 (2021).[Pubmed]
  • Takano, T. et al. Chemico-genetic discovery of astrocytic control of inhibition in vivo. Nature 588, 296–302 (2020).[Pubmed]
  • Sekiguchi, M. et al. ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk. Transl Psychiatry 10, 1–15 (2020).[Pumed]
  • Takano, T., Funahashi, Y. & Kaibuchi, K. Neuronal Polarity: Positive and Negative Feedback Signals. Front. Cell Dev. Biol. 7, (2019).[Pubmed]
  • Funahashi, Y. et al. Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors. Cell Reports 29, 3235-3252.e9 (2019).[Pubmed]
  • Nishino, H. et al. The LMTK1-TBC1D9B-Rab11A Cascade Regulates Dendritic Spine Formation via Endosome Trafficking. J. Neurosci. 39, 9491–9502 (2019).[Pubmed]
  • Takano, T. et al. Discovery of long-range inhibitory signaling to ensure single axon formation. Nat Commun 8, 33 (2017).[Pubmed]
  • Yura, Y. et al. Focused Proteomics Revealed a Novel Rho-kinase Signaling Pathway in the Heart. Cell Structure and Function 41, 105–120 (2016).[Pubmed]
  • Nagai, T. et al. Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo. Neuron 89, 550–565 (2016).[Pubmed]
  • Hamaguchi, T. et al. In vivo Screening for Substrates of Protein Kinase A Using a Combination of Proteomic Approaches and Pharmacological Modulation of Kinase Activity. Cell Struct. Funct. 40, 1–12 (2015).[Pubmed]
  • Namba, T. et al. Extracellular and Intracellular Signaling for Neuronal Polarity. Physiological Reviews 95, 995–1024 (2015).[Pubmed]
  • Takano, T., Xu, C., Funahashi, Y., Namba, T. & Kaibuchi, K. Neuronal polarization. Development 142, 2088–2093 (2015).[Pubmed]
  • Xu, C. et al. Radial Glial Cell–Neuron Interaction Directs Axon Formation at the Opposite Side of the Neuron from the Contact Site. J. Neurosci. 35, 14517–14532 (2015).[Pubmed]
  • Takano, T. et al. LMTK1 regulates dendritic formation by regulating movement of Rab11A-positive endosomes. Mol. Biol. Cell 25, 1755–1768 (2014).[Pubmed]
  • Namba, T. et al. Pioneering Axons Regulate Neuronal Polarization in the Developing Cerebral Cortex. Neuron 81, 814–829 (2014).[Pubmed]
  • Ito, Y. et al. Preferential targeting of p39-activated Cdk5 to Rac1-induced lamellipodia. Molecular and Cellular Neuroscience 61, 34–45 (2014).[Pubmed]

日本語総説

  • 松林潤平, 髙野哲也(2025), 近位依存性ビオチン標識（BioID）法を応用した脳内のシナプスプロテオーム, 日本生物学的精神医学会誌
  • 福田朱里, 髙野哲也(2025), BioID技術を用いたグリア細胞の網羅的な分子解析, 実験医学増刊
  • 永本紗也佳, 髙野哲也, 奥山一生 (2024), Split-BioID法とその派生技術の可能性 実験医学別冊 リアルな相互作用を捉える近接依存性標識プロトコール
  • 伊藤有紀, 髙野哲也 (2024), BioID法で解き明かす生体脳の空間プロテオーム 実験医学別冊 リアルな相互作用を捉える近接依存性標識プロトコール
  • 髙野哲也, 曽我部拓 , 柚﨑通介 (2024), 近接標識法と膨張顕微鏡法が解明するシナプスのすがた, 実験医学
  • 髙野哲也 (2023), 生体内近位依存性ビオチン標識法を用いた空間的分子探索, 生体の科学
  • 髙野哲也 (2021), 近位依存性ビオチン標識法Split-TurboIDが解き明かすアストロサイトによる抑制性シナプス制御機構, Neuroscience News, No.3
  • 髙野哲也 (2021), アストロサイトに見つかった抑制性シナプス制御機構, Natureダイジェスト, 4月号
  • 髙野哲也 (2021), 新たな近位依存性ビオチン標識Split-TurboID法が導く三者間シナプスの役割と機能, 実験医学, Vol39, No6, 4
  • 髙野哲也 (2021), 脳内のグリア細胞―神経細胞間コミュニケーションを解き明かす空間的分子探索技術の創出, 神経科学トピックス,
  • 髙野哲也 (2020), 脳内における三者間シナプスの空間的分子ネットワーク, 神経化学トピックス, , DOI 10.11481/topics142
  • 髙野哲也, 貝淵弘三 (2019), シグナルネットワークから神経細胞の極性化に迫る, 医学のあゆみ
  • 髙野哲也 (2018), 脳構築における神経細胞の極性形成と維持機構の解明, 機関誌「神経化学」